Impact of obesity in patients infected with 2009 influenza A(H1N1).
Identifieur interne : 000399 ( Main/Exploration ); précédent : 000398; suivant : 000400Impact of obesity in patients infected with 2009 influenza A(H1N1).
Auteurs : Emili Díaz [Oman] ; Alejandro Rodríguez ; Ignacio Martin-Loeches ; Leonardo Lorente ; María Del Mar Martín ; Juan Carlos Pozo ; Juan Carlos Montejo ; Angel Estella ; Ángel Arenzana ; Jordi Rello [Espagne]Source :
- Chest [ 1931-3543 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Enregistrements (MeSH), Espagne (épidémiologie), Facteurs de risque (MeSH), Femelle (MeSH), Grippe humaine (complications), Grippe humaine (mortalité), Grippe humaine (virologie), Humains (MeSH), Indice APACHE (MeSH), Loi du khi-deux (MeSH), Modèles des risques proportionnels (MeSH), Mâle (MeSH), Observation (MeSH), Obésité (complications), Obésité (mortalité), RT-PCR (MeSH), Sous-type H1N1 du virus de la grippe A (MeSH), Statistique non paramétrique (MeSH), Unités de soins intensifs (statistiques et données numériques), Études prospectives (MeSH).
- MESH :
- mortalité : Grippe humaine, Obésité.
- statistiques et données numériques : Unités de soins intensifs.
- virologie : Grippe humaine.
- épidémiologie : Espagne.
- complications : Adulte, Adulte d'âge moyen, Enregistrements, Facteurs de risque, Femelle, Grippe humaine, Humains, Indice APACHE, Loi du khi-deux, Modèles des risques proportionnels, Mâle, Observation, Obésité, RT-PCR, Sous-type H1N1 du virus de la grippe A, Statistique non paramétrique, Études prospectives.
English descriptors
- KwdEn :
- APACHE (MeSH), Adult (MeSH), Chi-Square Distribution (MeSH), Female (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (complications), Influenza, Human (mortality), Influenza, Human (virology), Intensive Care Units (statistics & numerical data), Male (MeSH), Middle Aged (MeSH), Obesity (complications), Obesity (mortality), Observation (MeSH), Proportional Hazards Models (MeSH), Prospective Studies (MeSH), Registries (MeSH), Reverse Transcriptase Polymerase Chain Reaction (MeSH), Risk Factors (MeSH), Spain (epidemiology), Statistics, Nonparametric (MeSH).
- MESH :
- complications : Influenza, Human, Obesity.
- epidemiology : Spain.
- mortality : Influenza, Human, Obesity.
- statistics & numerical data : Intensive Care Units.
- virology : Influenza, Human.
- APACHE, Adult, Chi-Square Distribution, Female, Humans, Influenza A Virus, H1N1 Subtype, Male, Middle Aged, Observation, Proportional Hazards Models, Prospective Studies, Registries, Reverse Transcriptase Polymerase Chain Reaction, Risk Factors, Statistics, Nonparametric.
Abstract
OBJECTIVE
A large proportion of patients infected with 2009 influenza A(H1N1) (A[H1N1]) are obese. Obesity has been proposed as a risk factor influencing outcome in these patients. However, its role remains unclear. We evaluate the outcome of patients who are obese and infected with A(H1N1) in the ICU, determining whether obesity is a risk factor for mortality.
METHODS
This was a prospective, observational, and multicenter study performed in 144 ICUs in Spain. Data were obtained from the Grupo de Trabajo en Enfermedades Infecciosas de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (GTEI/SEMICYUC) registry. Adult patients with A(H1N1) that was confirmed by real-time polymerase chain reaction were included in the analysis. Patients who were obese (BMI > 30) were compared with patients who were nonobese. Cox regression analysis was used to determine adjusted mortality. Differences of P < .05 were considered significant.
RESULTS
In January 2010, the GTEI/SEMICYUC registry had complete records for 416 patients. One hundred and fifty patients (36.1%) were obese, of whom 67 (44.7%) were morbidly obese (BMI > 40). Mechanical ventilation (MV) was more frequently applied in patients who were obese (64% vs 52.4%, P < .01) Patients with obesity remained on MV longer than patients who were nonobese (6.5 ± 10.3 days vs 9.3 ± 9.7 days, P = .02), had longer ICU length of stay (10.8 ± 12.1 days vs 13.7 ± 11.7 days, P = .03), and had longer hospitalization (18.2 ± 14.6 days vs 22.2 ± 16.5 days, P = .02). Mortality adjusted by severity and potential confounders identified that obesity was not significantly associated with ICU mortality (hazard ratio, 1.1; 95% CI, 0.69-1.75; P = .68).
CONCLUSIONS
In our cohort, patients who were obese and infected with A(H1N1) did not have increased mortality. However, there was an association between obesity and higher ICU resource consumption.
DOI: 10.1378/chest.10-1160
PubMed: 20688928
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Díaz</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario Joan XXIII-Centro de Investigación Biomédica en red Enfermedades Respiratorias, Universitat Rovira i Virgili (URV), and Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona. Electronic address: emilio.diaz.santos@gmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country></affiliation></author><author><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodríguez">Alejandro Rodríguez</name><affiliation><nlm:affiliation>Critical Care Department, Hospital Universitario Joan XXIII-Centro de Investigación Biomédica en red Enfermedades Respiratorias, Universitat Rovira i Virgili (URV), and Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona.</nlm:affiliation><wicri:noCountry code="subField">Tarragona</wicri:noCountry></affiliation></author><author><name sortKey="Martin Loeches, Ignacio" sort="Martin Loeches, Ignacio" uniqKey="Martin Loeches I" first="Ignacio" last="Martin-Loeches">Ignacio Martin-Loeches</name><affiliation><nlm:affiliation>Critical Care Department, Hospital Universitario Joan XXIII-Centro de Investigación Biomédica en red Enfermedades Respiratorias, Universitat 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last="Pozo">Juan Carlos Pozo</name><affiliation><nlm:affiliation>Hospital de la Candelaria, Tenerife the Critical Care Department, Hospital Reina Sofía, Córdoba.</nlm:affiliation><wicri:noCountry code="subField">Córdoba</wicri:noCountry></affiliation></author><author><name sortKey="Montejo, Juan Carlos" sort="Montejo, Juan Carlos" uniqKey="Montejo J" first="Juan Carlos" last="Montejo">Juan Carlos Montejo</name><affiliation><nlm:affiliation>Critical Care Department, Hospital Sistema Andaluz de Salud, Jerez.</nlm:affiliation><wicri:noCountry code="subField">Jerez</wicri:noCountry></affiliation></author><author><name sortKey="Estella, Angel" sort="Estella, Angel" uniqKey="Estella A" first="Angel" last="Estella">Angel Estella</name><affiliation><nlm:affiliation>Hospital 12 de Octubre, Madrid the Critical Care Department, Hospital Sistema Andaluz de Salud, Jerez.</nlm:affiliation><wicri:noCountry code="subField">Jerez</wicri:noCountry></affiliation></author><author><name sortKey="Arenzana, Angel" sort="Arenzana, Angel" uniqKey="Arenzana A" first="Ángel" last="Arenzana">Ángel Arenzana</name><affiliation><nlm:affiliation>Critical Care Department, Virgen de la Macarena, Sevilla.</nlm:affiliation><wicri:noCountry code="subField">Sevilla</wicri:noCountry></affiliation></author><author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name><affiliation wicri:level="4"><nlm:affiliation>Critical Care Department, Vall D'Hebron Hospital, Universitat Autònoma de Barcelona, Institut de Recerca Vall D'Hebron Centro de Investigación Biomédica en red de Enfermedades Respiratorias, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Vall D'Hebron Hospital, Universitat Autònoma de Barcelona, Institut de Recerca Vall D'Hebron Centro de Investigación Biomédica en red de Enfermedades Respiratorias, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author></analytic><series><title level="j">Chest</title><idno type="eISSN">1931-3543</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>APACHE (MeSH)</term><term>Adult (MeSH)</term><term>Chi-Square Distribution (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (MeSH)</term><term>Influenza, Human (complications)</term><term>Influenza, Human (mortality)</term><term>Influenza, Human (virology)</term><term>Intensive Care Units (statistics & numerical data)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Obesity (complications)</term><term>Obesity (mortality)</term><term>Observation (MeSH)</term><term>Proportional Hazards Models (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Registries (MeSH)</term><term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term><term>Risk Factors (MeSH)</term><term>Spain (epidemiology)</term><term>Statistics, Nonparametric (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Enregistrements (MeSH)</term><term>Espagne (épidémiologie)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (complications)</term><term>Grippe humaine (mortalité)</term><term>Grippe humaine (virologie)</term><term>Humains (MeSH)</term><term>Indice APACHE (MeSH)</term><term>Loi du khi-deux (MeSH)</term><term>Modèles des risques proportionnels (MeSH)</term><term>Mâle (MeSH)</term><term>Observation (MeSH)</term><term>Obésité (complications)</term><term>Obésité (mortalité)</term><term>RT-PCR (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (MeSH)</term><term>Statistique non paramétrique (MeSH)</term><term>Unités de soins intensifs (statistiques et données numériques)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term><term>Obésité</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Unités de soins intensifs</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term></keywords><keywords scheme="MESH" xml:lang="en"><term>APACHE</term><term>Adult</term><term>Chi-Square Distribution</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Male</term><term>Middle Aged</term><term>Observation</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>Registries</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Risk Factors</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enregistrements</term><term>Facteurs de risque</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Indice APACHE</term><term>Loi du khi-deux</term><term>Modèles des risques proportionnels</term><term>Mâle</term><term>Observation</term><term>Obésité</term><term>RT-PCR</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Statistique non paramétrique</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>A large proportion of patients infected with 2009 influenza A(H1N1) (A[H1N1]) are obese. Obesity has been proposed as a risk factor influencing outcome in these patients. However, its role remains unclear. We evaluate the outcome of patients who are obese and infected with A(H1N1) in the ICU, determining whether obesity is a risk factor for mortality.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>This was a prospective, observational, and multicenter study performed in 144 ICUs in Spain. Data were obtained from the Grupo de Trabajo en Enfermedades Infecciosas de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (GTEI/SEMICYUC) registry. Adult patients with A(H1N1) that was confirmed by real-time polymerase chain reaction were included in the analysis. Patients who were obese (BMI > 30) were compared with patients who were nonobese. Cox regression analysis was used to determine adjusted mortality. Differences of P < .05 were considered significant.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In January 2010, the GTEI/SEMICYUC registry had complete records for 416 patients. One hundred and fifty patients (36.1%) were obese, of whom 67 (44.7%) were morbidly obese (BMI > 40). Mechanical ventilation (MV) was more frequently applied in patients who were obese (64% vs 52.4%, P < .01) Patients with obesity remained on MV longer than patients who were nonobese (6.5 ± 10.3 days vs 9.3 ± 9.7 days, P = .02), had longer ICU length of stay (10.8 ± 12.1 days vs 13.7 ± 11.7 days, P = .03), and had longer hospitalization (18.2 ± 14.6 days vs 22.2 ± 16.5 days, P = .02). Mortality adjusted by severity and potential confounders identified that obesity was not significantly associated with ICU mortality (hazard ratio, 1.1; 95% CI, 0.69-1.75; P = .68).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>In our cohort, patients who were obese and infected with A(H1N1) did not have increased mortality. However, there was an association between obesity and higher ICU resource consumption.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20688928</PMID><DateCompleted><Year>2011</Year><Month>03</Month><Day>17</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1931-3543</ISSN><JournalIssue CitedMedium="Internet"><Volume>139</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Chest</Title><ISOAbbreviation>Chest</ISOAbbreviation></Journal><ArticleTitle>Impact of obesity in patients infected with 2009 influenza A(H1N1).</ArticleTitle><Pagination><MedlinePgn>382-386</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0012-3692(11)60079-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1378/chest.10-1160</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">A large proportion of patients infected with 2009 influenza A(H1N1) (A[H1N1]) are obese. Obesity has been proposed as a risk factor influencing outcome in these patients. However, its role remains unclear. We evaluate the outcome of patients who are obese and infected with A(H1N1) in the ICU, determining whether obesity is a risk factor for mortality.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This was a prospective, observational, and multicenter study performed in 144 ICUs in Spain. Data were obtained from the Grupo de Trabajo en Enfermedades Infecciosas de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (GTEI/SEMICYUC) registry. Adult patients with A(H1N1) that was confirmed by real-time polymerase chain reaction were included in the analysis. Patients who were obese (BMI > 30) were compared with patients who were nonobese. Cox regression analysis was used to determine adjusted mortality. Differences of P < .05 were considered significant.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In January 2010, the GTEI/SEMICYUC registry had complete records for 416 patients. One hundred and fifty patients (36.1%) were obese, of whom 67 (44.7%) were morbidly obese (BMI > 40). Mechanical ventilation (MV) was more frequently applied in patients who were obese (64% vs 52.4%, P < .01) Patients with obesity remained on MV longer than patients who were nonobese (6.5 ± 10.3 days vs 9.3 ± 9.7 days, P = .02), had longer ICU length of stay (10.8 ± 12.1 days vs 13.7 ± 11.7 days, P = .03), and had longer hospitalization (18.2 ± 14.6 days vs 22.2 ± 16.5 days, P = .02). Mortality adjusted by severity and potential confounders identified that obesity was not significantly associated with ICU mortality (hazard ratio, 1.1; 95% CI, 0.69-1.75; P = .68).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In our cohort, patients who were obese and infected with A(H1N1) did not have increased mortality. However, there was an association between obesity and higher ICU resource consumption.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Díaz</LastName><ForeName>Emili</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario Joan XXIII-Centro de Investigación Biomédica en red Enfermedades Respiratorias, Universitat Rovira i Virgili (URV), and Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona. Electronic address: emilio.diaz.santos@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario Joan XXIII-Centro de Investigación Biomédica en red Enfermedades Respiratorias, Universitat Rovira i Virgili (URV), and Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin-Loeches</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario Joan XXIII-Centro de Investigación Biomédica en red Enfermedades Respiratorias, Universitat Rovira i Virgili (URV), and Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lorente</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Canarias, Tenerife.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Del Mar Martín</LastName><ForeName>María</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Reina Sofía, Córdoba.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pozo</LastName><ForeName>Juan Carlos</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Hospital de la Candelaria, Tenerife the Critical Care Department, Hospital Reina Sofía, Córdoba.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montejo</LastName><ForeName>Juan Carlos</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Sistema Andaluz de Salud, Jerez.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Estella</LastName><ForeName>Angel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hospital 12 de Octubre, Madrid the Critical Care Department, Hospital Sistema Andaluz de Salud, Jerez.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arenzana</LastName><ForeName>Ángel</ForeName><Initials>Á</Initials><AffiliationInfo><Affiliation>Critical Care Department, Virgen de la Macarena, Sevilla.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rello</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Critical Care Department, Vall D'Hebron Hospital, Universitat Autònoma de Barcelona, Institut de Recerca Vall D'Hebron Centro de Investigación Biomédica en red de Enfermedades Respiratorias, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>H1N1 SEMICYUC Working Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>08</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Chest</MedlineTA><NlmUniqueID>0231335</NlmUniqueID><ISSNLinking>0012-3692</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018806" MajorTopicYN="N">APACHE</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016009" MajorTopicYN="N">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009765" MajorTopicYN="N">Obesity</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019370" MajorTopicYN="N">Observation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012042" MajorTopicYN="N">Registries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018709" MajorTopicYN="N">Statistics, Nonparametric</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20688928</ArticleId><ArticleId IdType="pii">S0012-3692(11)60079-2</ArticleId><ArticleId IdType="doi">10.1378/chest.10-1160</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li><li>Oman</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement><orgName><li>Université autonome de Barcelone</li></orgName></list><tree><noCountry><name sortKey="Arenzana, Angel" sort="Arenzana, Angel" uniqKey="Arenzana A" first="Ángel" last="Arenzana">Ángel Arenzana</name><name sortKey="Del Mar Martin, Maria" sort="Del Mar Martin, Maria" uniqKey="Del Mar Martin M" first="María" last="Del Mar Martín">María Del Mar Martín</name><name sortKey="Estella, Angel" sort="Estella, Angel" uniqKey="Estella A" first="Angel" last="Estella">Angel Estella</name><name sortKey="Lorente, Leonardo" sort="Lorente, Leonardo" uniqKey="Lorente L" first="Leonardo" last="Lorente">Leonardo Lorente</name><name sortKey="Martin Loeches, Ignacio" sort="Martin Loeches, Ignacio" uniqKey="Martin Loeches I" first="Ignacio" last="Martin-Loeches">Ignacio Martin-Loeches</name><name sortKey="Montejo, Juan Carlos" sort="Montejo, Juan Carlos" uniqKey="Montejo J" first="Juan Carlos" last="Montejo">Juan Carlos Montejo</name><name sortKey="Pozo, Juan Carlos" sort="Pozo, Juan Carlos" uniqKey="Pozo J" first="Juan Carlos" last="Pozo">Juan Carlos Pozo</name><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodríguez">Alejandro Rodríguez</name></noCountry><country name="Oman"><noRegion><name sortKey="Diaz, Emili" sort="Diaz, Emili" uniqKey="Diaz E" first="Emili" last="Díaz">Emili Díaz</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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